Medication Administration Errors | PSNet (2023)

Paul MacDowell, PharmD, BCPS, Ann Cabri, PharmD, and Michaela Davis, MSN, RN, CNS | March 12, 2021

Updated in March 2021.Originally published in January 2018 by researchers at the University of California, San Francisco. PSNet primers are regularly reviewed and updated to ensure that they reflect current research and practice in the patient safety field.


Medication errors have been a key target for improving safety since Bates and colleagues' reports in the 1990s characterized the frequency of adverse drug events (ADEs) and the relationship between medication errors and ADEs in hospitalized patients. As described in related primers on medication errors and adverse drug events and on the pharmacist's role in medication safety, the medication-use process is highly complex with many steps and risk points for error. This primer will focus on nurse-related medication administration errors.

Medication administration errors are typically thought of as a failure in one of the five “rights” of medication administration (right patient, medication, time, dose, and route). These five “rights” have been historically incorporated into the nursing curriculum as the standard processes to ensure safe medication administration. Recent literature, however, has emphasized that medication administration is part of a complex medication use process, in which a multidisciplinary care team works together to ensure patient-centered care delivery. As such, it has been emphasized that the five “rights” do not ensure administration safety as a standalone process. Therefore, four additional “rights” were proposed to include right documentation, action/reason, form, and response.1 As modern healthcare delivery systems continue to evolve, emphasis on system design (i.e. technology & clinical workflows) has become a priority to complement the medication administration process. System-related causes of medication administration errors may include inadequate training, distractors, convoluted processes, and system misconfiguration.2

Despite error reduction efforts through implementing new technologies and streamlining processes, medication administration errors remain prevalent. In a review of 91 direct observation studies of medication errors in hospitals and long-term care facilities, investigators estimated median error rates of 8%–25% during medication administration. Intravenous administration had a higher error rate, with an estimated median rate (including timing errors) ranging from 48%–53%.

(Video) Medication Error Training Video

A substantial proportion of medication administration errors occur in hospitalized children. This is largely due to the complexity of weight-based pediatric dosing, which encompasses medication doses based on calculations from weight and sometimes height. Variability of weights used for calculation can increase medication dose errors.6 Given this variability, dose preparation is uniquely challenging in pediatric populations, which increases risk for wrong dose administration.

Outside of the hospital setting, patients and caregivers are also at high risk for making errors. Errors in the home are reported to occur at rates between 2-33%. Wrong dose, missing doses, and wrong medication are the most commonly reported administration errors. Contributing factors to patient and caregiver error include low health literacy, poor provider–patient communication, absence of health literacy, and universal precautions in the outpatient clinic.


Both low- and high-tech strategies have been designed to ensure safe medication administration and align with the nine rights of medication administration. Many low-tech strategies support all nine rights, including the use of standardized communication strategies and independent double check workflows.

Low-tech solutions

Standardized communication: Health system communication standards are used to ensure right medication. Tall man lettering is used in various electronic health records (EHRs), product labeling, and drug information resources to alert readers to “look alike, sound alike” drug names. Additionally, standard abbreviations and numerical conventions are recommended by The Joint Commission.3 The ‘do not use’ list includes general standards for expression of numeric doses. Of note, leading and trailing decimals (i.e., 0.2mg and 2.0 mg) are discouraged due to the potential for misreading (i.e., 20 mg).3


Patient Education: To mitigate risk of error in the home, it is important for health care professionals to use clear communication strategies and routinely provide education to patients, especially when medication regimens are modified.4 A related primer on health literacy outlines some of the difficulties patients and family members encounter in understanding their medication regimens, as well as interventions for improving communication and understanding.

Patient education is a core component of medication management, particularly with high-risk medications such as anticoagulation therapy. Patients are educated routinely to ensure understanding of indication for therapy, intended outcomes, and signs and symptoms of adverse events. To help mitigate of wrong dose errors, warfarin tablet colors are standardized by their strength across all manufacturers. Patients are often advised to double check their tablet color upon getting a new prescription refill. If the prescription didn’t change, the tablet color shouldn’t either.

Optimizing Nursing Workflow to Minimize Error Potential: In health care settings, distractors during the medication administration process are common and associated with increased risk and severity of errors. Minimizing interruptions during medication administration and building in safety checks through standardized workflows are key strategies to facilitate safe administration. There are many challenges associated with a true distraction-free zone; a study assessing feasibility of a "do not interrupt" bundle found that it was moderately effective but had limited acceptability and sustainability. Areas of increased high-risk medications administrations, such as the intensive care unit or emergency department, may have decreased compliance with non-interruption zones due to workflows and frequency of medication passes and titration events. Health systems should identify the area where medication administration preparation by nurses occurs to ensure that minimal disruptions are present (i.e., medication rooms, medication carts).

Additionally, strategies such as independent double checks are part of optimizing medication safety through nursing workflows. The Institute for Safe Medication Practices (ISMP) also recommends judicious use of independent double checks involving two different nurses to intercept errors prior to administration with key high-alert medications.4 Double check processes involve a completely independent evaluation by a second nurse prior to administration. Research by Campbell et al. suggests that 93% of errors may be detected through this workflow, but only when performed as a true independent double check. Due to the additional time burden added to existing nursing workload, these double checks should be strategically targeted to the highest-risk medications and processes. Independent double checks should include “walking” or tracing the infusion lines from the infusion pump to the vascular access to ensure the intended medication is attached and infusing.

Some medications are available in a specific format to ensure the correct route is utilized during administration. For example, the epinephrine auto injector (EpiPen) for treatment of anaphylaxis is provided in a ready-to-use pen. This device, used for intramuscular injection in an emergency, does not connect to an intravenous (IV) line, thus preventing unintended administration via the IV route. Similarly, Enfit connectors and syringes for oral/g-tube/NG tube help to prevent inadvertent connection and administration of oral medications into an IV line.

Another crucial educational tool for health systems is the use of medication pass audits or medication safety rounds. These sessions involving an institution’s managers and clinical experts serve as method of validating correct individual practice and serve as an opportunity to provide ‘just in time’ education. Audits of the administration process not only validate adherence to protocols but may highlight system processes that may need improvement to facilitate nurses’ compliance.

(Video) Medication & Error Prevention: Case Studies

Focusing in on High-Risk Agents: Some classes of medications have a higher likelihood to result in patient harm when involved in an administration error. Examples of these “high alert” medications include anticoagulants, insulins, opioids, and chemotherapeutic agents. The ISMP recommends a multipronged approach to mitigating risk with use of these agents. Strategies to mitigate potential for an administration error include protocolized prescribing, simplified instruction, robust documentation, and use of standardized administration practices such as dual nurse verification at the bedside. Health systems are encouraged to develop robust guidelines for use of these agents.

Standardized labeling, clear storage requirements, and various clinical decision support strategies are used to ensure correct medication selection and administration technique. The appearance of the medication itself may serve as a valuable safeguard. As an example, one type of eye drops (prostaglandins) has a turquoise cap on the bottle, across all manufacturers, while another completely different type of eye drop has a pink cap (steroids). This distinguishing feature may be helpful for caregivers and patients alike, especially given that low-vision patients frequently use these drops. Similar techniques are employed with institutional labeling. If a medication is supplied in a consistent manner with specific labeling, this may also reduce error. Pharmacy-prepared emergency kits frequently employ standardized labeling and instructions for this reason. Ensuring that certain medications are only supplied in a ‘pharmacy kit’ is one strategy for helping to standardize process and reduce opportunity for error during administration.

High Tech Solutions

High-tech solutions commonly implemented within health systems include: barcode scanning of medication to ensure right medication, patients arm bands to confirm the right medication and the right patient, and smart infusion pumps for IV administration to confirm the right administration rate (a derivative of right dose and route) with technology that inhibits over- and underdosing of titratable drips during pump programming.

Barcode medication administration: When used appropriately, barcode medication administration (BCMA) technology reduces errors in health system settings by using barcode labeling of patients, medications, and medical records to electronically link the right dose of the right medication to the right patient at the right time. A study of non-timing medication errors in a system with comprehensive barcoding/electronic medical administration technology found a 41% reduction in errors and a 51% decrease in potential adverse drug events. Timing errors were also reduced by 27% in this study. However, BCMA is subject to a number of usability issues and workarounds that can degrade its effectiveness in practice. Users may encounter blockades in the BCMA workflow, for example, when the patient's arm band is not readable, the medication is not labeled or not in the system, or the scanning equipment malfunctions. A Dutch study using direct observation in four hospitals found that nurses used workarounds to solve BCMA workflow blockades in more than two-thirds of medication administrations, and workarounds were associated with a threefold higher risk of medication error.

Smart infusion pumps: The use of smart infusion pumps, or infusion pumps with Dose Error Reduction Software (DERS), has increased substantially in recent years. According to a 2017 survey, 88% of hospitals in the United States utilized smart infusion pumps. Although smart pumpsoffer numerous safety advantages, they are also prone to implementation and human factors problems, such as difficult user interfaces and complex programming requirements that create opportunities for serious errors. Use of the drug library to ensure accurate pump programming is a key workflow step; not using the drug library as intended may negate the benefits of smart pump technology. Evidence suggests variable use of the drug library as intended; one study noted use ranging from 62% to 98%.

(Video) Medication errors can occur due to both human error and system errors healthcare

Given the complexity of manual pump programming, technologic advances allow for smart pump interoperability with the EHR, which allows the smart infusion pump screen to be pre-populated with information from the EHR. With an interconnected system of prepopulated smart pumps, additional resources may be needed to keep the system working its best. Challenges include keeping DERS in the smart pump aligned with most current hospital practice, ensuring standardization across care areas and devices, and data collection and ongoing quality improvement.

Some new technology supports the caregiver in assessing for the correct patient response to a medication. For example, some patient controlled analgesia pumps (PCAs) can be linked to an End Tidal CO2 monitor. If retention of CO2 is detected, above a set threshold, this may indicate over sedation and respiratory depression. Based on this trigger, the pump can stop the PCA infusion, which may, in turn, reduce the possibility of further respiratory decline. While this a helpful tool, manual assessment of patient response for medication therapy still remains of the upmost importance.

Current Context

Steps in the medication pathway are complex and interconnected. The healthcare industry utilizes a number of low-tech and high-tech strategies to mitigate risk of medication administration errors. Safety advancements require a comprehensive, systems-oriented approach that considers all aspects of the medication-use process in a multidisciplinary approach with input from clinical specialists (nurses, physicians, pharmacists), informatics & automation specialists, safety & regulatory experts, as well as patients and family.

Paul MacDowell, PharmD, BCPS
Department of Pharmacy Services
UC Davis Health

Ann Cabri, PharmD
Department of Pharmacy Services
UC Davis Health

Michaela Davis, MSN, RN, CNS
Doctoral Student
Betty Irene Moore School of Nursing
UC Davis

(Video) Medication Errors


  1. Elliott M, Liu Y. The nine rights of medication administration: an overview.Br J Nurs. 2010;19(5):300-305. [Available at] doi:10.12968/bjon.2010.19.5.47064.
  2. National Coordinating Council for Medication Error Reporting. “Taxonomy of Medication Errors”. Available at: Accessed December 2020.
  3. The Joint Commission. Official “Do Not Use” List. Available at: Accessed December 2020.
  4. Give strategies for providing effective patient education. Expert Insights. Wolters Kluwer. Accessed February 2021.
  5. Campbell GM, Facchinetti NJ. Using process control charts to monitor dispensing and checking errors. Am J Health Syst Pharm. 1998;55(9):946-952. doi:10.1093/ajhp/55.9.946. [Available at]
  6. Gonzales, K. Medication administration errors and the pediatric population: a systematic search of the literature.J Pediatr Nurs. 2010;25(6):555-565. [Available at]


How do you respond to a medication error? ›

Respond to the report immediately with concern. Assure the patient that the situation is important and a priority. Remedy the immediate situation with truth and honesty. Be direct and open with the patient reporting the error.

What do you do if a medication administration error is made? ›

If an error occurs, the appropriate steps should be taken to address the patient's condition. It is important to document the incident or near-miss and report it immediately to the patient's primary healthcare provider and your employer. In addition, complete any additional documentation required by your employer.

What is the most common error in medication administration? ›

The most common types of reported errors were wrong dosage and infusion rate. The most common causes were using abbreviations instead of full names of drugs and similar names of drugs. Therefore, the most important cause of medication errors was lack of pharmacological knowledge.

What is the percentage of medication errors? ›

In a review of 91 direct observation studies of medication errors in hospitals and long-term care facilities, investigators estimated median error rates of 8%–25% during medication administration.

When a medication error occurs you should first? ›

Which should be the first step if a medication error occurs? Notify the physician that the wrong medication has been given. Medication errors with parenteral medications can be easily corrected if caught within 10 minutes.

What happens if a nurse makes a med error? ›

For a nurse who makes a medication error, consequences may include disciplinary action by the state board of nursing, job dismissal, mental anguish, and possible civil or criminal charges.

What action should a nurse take first when a medication error is made? ›

someone else has made a medication error, you must IMMEDIATELY REPORT THE ERROR TO THE RN CM/DN AND APPROPRIATELY DOCUMENT THE ERROR. According to your agency's policy, your supervisor should also be notified.

Can a nurse get fired for a med error? ›

The consequences will depend largely on the policy of your employer, and fortunately, most accept that mistakes do happen and will not dismiss an employee for a first mistake.

Which must be completed if a medication error occurs? ›

Any staff member who discovers a medication error, whether a physician, pharmacist or nurse, must immediately complete the Medication Error Report (Appendix I). The details include; patient name, hospital number, prescription details, details of errors and any incorrect medicine or dose administered to the patient.

What are the top 5 medication errors? ›

Top 5 Most Common Prescription Drug Errors
  1. Lack of awareness of expiration dates. Although expiration dates are printed on the bottle or label, many patients do not pay attention to the date. ...
  2. Taking the incorrect dosage. ...
  3. Rate of usage. ...
  4. What time of day to take the drug. ...
  5. Combining drugs without physician guidance.
Jan 17, 2017

What is the most common reason for drug errors? ›

Most medication errors occur at the time of administration (Miller and Emanuel, 2010). Many are caused by inadequate prescribing, dispensing, updating of prescriptions and administering of drugs (Royal Pharmaceutical Society, 2009).

What is the most common stage for medication errors to occur? ›

Medication errors can occur at many steps in patient care, from ordering the medication to the time when the patient is administered the drug. In general, medication errors usually occur at one of these points: Ordering/prescribing. Documenting.

How common is medical error? ›

Medication errors are common in hospitals, but only about 1 in a 100 actually results in harm to the patient. Conversely, only about 30% of injuries due to drugs in hospitals are associated with a medication error, and are thus preventable.

What percentage of medication errors are preventable? ›

Up to 80% of harm is preventable. The most detrimental errors are related to diagnosis, prescription and the use of medicines (6).

Who is responsible for a medication error? ›

Who Can Be Liable for Prescription Drug Errors? In a nutshell, anyone and everyone along the chain of prescribing and administering a medication can be liable for prescription drug errors. This includes doctors, nurses, hospitals, the pharmacy departments in hospitals, pharmacists, and the pharmaceutical manufacturer.

What is the best way for nurses to prevent medication errors? ›

To safeguard against medication errors, nurses must implement the proper procedures for medication administration, including at least these five rights: right patient, drug, dose, route, and time. In addition, they must complete accurate documentation once the patient receives the medication.

What happens when a medication error occurs? ›

Some medication errors change a patient's outcome, but the change does not result in any harm. Other medication errors have the potential to cause harm, but they do not actually cause harm. Serious medication errors that are not intercepted, however, will actually harm the patient.

What is the most common error in nursing? ›

#1 Errors with Medication

For new nurses, the most common cause of errors with medication is a lack of 'presence of mind', as well as nerves and pressure. Studies have shown that administration errors can account for anywhere up to 32% of medication errors.

What is the process for reporting a medication error? ›

Any staff member who discovers a medication error, whether a physician, pharmacist or nurse, must immediately complete the Medication Error Report (Appendix I). The details include; patient name, hospital number, prescription details, details of errors and any incorrect medicine or dose administered to the patient.

How do you apologize for medical errors? ›

Get the facts. Don't simply react with emotion or guilt. If an apology is, indeed, warranted, make sure that it is sincere. Acknowledge the error, give the patient an explanation of what happened, express your remorse that it happened, and outline what steps you will take to make reparation.

What would you do if you accidentally commit a wrong dispensing? ›

Here is a brief outline of what to do if you become a victim of a pharmacy error:
  1. Call your Doctor Right Away.
  2. Call the Pharmacy Immediately.
  3. Do NOT Give the Mis-Filled Medication Under Any Circumstance.
  4. Save the Unused Medication.
  5. Save the Bag.
  6. Save the Receipt.
  7. Save the Empty Bottle.

What happens when a medication error occurs? ›

Some medication errors change a patient's outcome, but the change does not result in any harm. Other medication errors have the potential to cause harm, but they do not actually cause harm. Serious medication errors that are not intercepted, however, will actually harm the patient.


1. DR010: Medication Safety - Safety and Errors in Nursing Pharmacology
2. How To Prevent Becoming A Victim of Medication Errors | Dr. Lusia Fomuso | TEDxPleasantGrove
(TEDx Talks)
3. Rights of Medication Administration in Nursing (5, 6, 7, 9, 10, 12) NCLEX Review
4. Medication errors in Healthcare organizations by Sundeep Kaur
(Quality Management & educational series)
5. The role of staff relationships in preventing medication errors
6. Tips for Preventing Medical Errors & Medication Mistakes
Top Articles
Latest Posts
Article information

Author: Francesca Jacobs Ret

Last Updated: 03/30/2023

Views: 5546

Rating: 4.8 / 5 (48 voted)

Reviews: 87% of readers found this page helpful

Author information

Name: Francesca Jacobs Ret

Birthday: 1996-12-09

Address: Apt. 141 1406 Mitch Summit, New Teganshire, UT 82655-0699

Phone: +2296092334654

Job: Technology Architect

Hobby: Snowboarding, Scouting, Foreign language learning, Dowsing, Baton twirling, Sculpting, Cabaret

Introduction: My name is Francesca Jacobs Ret, I am a innocent, super, beautiful, charming, lucky, gentle, clever person who loves writing and wants to share my knowledge and understanding with you.